A retrospective natural history study of patients (pts) with PDGFRα D842V mutant advanced gastrointestinal stromal tumor (GIST) previously treated with a tyrosine kinase inhibitor (TKI).

Abstract

11533Background: Activating mutations in KIT or PDGFRA kinases drive the vast majority of GIST in adult pts, making the disease highly amenable to targeted therapy. KIT-driven disease is more commo...