Abstract
The objective of this study was to evaluate the relationship between individual characteristics and deep tissue infections in patients enrolled in opioid agonist treatment in Ontario, Canada. A retrospective cohort study was conducted on patients in opioid agonist treatment between January 1, 2011, and December 31, 2015 in Ontario, Canada. Patients were identified using data from the Ontario Health Insurance Plan Database, and the Ontario Drug Benefit Plan Database. We identified other study variables including all-cause mortality using data from the Registered Persons Database. Encrypted patient identifiers were used to link across databases. Logistic regression models were used to measure potential correlates of deep tissue infections. An increase in the incidence of deep tissue infections was observed between 2011 and 2016 for patients on opioid agonist treatment. Additionally, age, sex, positive HIV diagnosis, and all-cause mortality was correlated with deep tissue infection in our study population. The study indicates factors that are associated with deep tissue infections in the opioid use disorder population and can be used to identify opportunities to reduce the incidence of new infections.
Highlights
Deep tissue infections (DIT) are pathogenic infections involving subcutaneous tissues that may proliferate to surrounding tissues and muscles [1]
Age, sex, positive Human Immunodeficiency Virus (HIV) diagnosis, and all-cause mortality was correlated with deep tissue infection in our study population
The study indicates factors that are associated with deep tissue infections in the opioid use disorder population and can be used to identify opportunities to reduce the incidence of new infections
Summary
Deep tissue infections (DIT) are pathogenic infections involving subcutaneous tissues that may proliferate to surrounding tissues and muscles [1]. This is due to the introduction of bacteria into the venous circulation or subcutaneous tissue, which is common among those who inject drugs [2, 3]. Individuals with opioid use disorder (OUD) have an increased risk of acquiring deep tissue infections due to the high prevalence of subcutaneous injections [3, 8,9,10,11,12,13,14,15,16,17,18,19,20]. OAT rates have been used to measure the prevalence of OUD in the population [23,24,25]
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