A Retrospective Analysis of Crayfish-Related Rhabdomyolysis (Haff Disease).

Changbao Huang,Weihua Wang,Liangfei Peng,Cheng Xue,Jinghan Jiang,Nengkai Gong

doi:10.1155/2019/4209745

Abstract

Objective To investigate the epidemiologic and etiologic factors, clinical features, therapeutic regimen, and prognosis of crayfish-related rhabdomyolysis (Haff disease). Methods Retrospectively analyzed the clinical data of 29 patients with crayfish-related rhabdomyolysis (Haff disease) from July to August 2016, summarized the clinical characteristics, and evaluated the prognosis. Results Clinical data of a total of 29 cases of Haff disease were retrospectively analyzed. The disease onset occurred after consumption of cooked crayfish with the incubation period ranging from 1 h to 48 h. There were no gender differences and significantly elevated CK in the duration with peak value of 41575.0U/L; the median value was 2445.0U/L (range: from 1187.0 U/L to 4722.0 U/L) and there was coincident elevated CK-MB. There was also no hepatorenal damage and transient urinalysis was abnormal. The most common presenting symptoms were myalgia (100%), weakness and numbness (51.7%), chest tightness and chest pain (41.4%), back pain (41.4%), and extremities pain (37.9%). All the patients recovered and no patients died. Conclusions Crayfish-related rhabdomyolysis (Haff disease) is a kind of a case or cluster of patients present with severe myalgia or weakness of unknown etiology and mechanism disease; however, the clinical signs and symptoms are relatively mild with favorable outcome.

Highlights

Rhabdomyolysis (RM) is a group of clinical syndromes, which is characterized by myalgia, myasthenia, muscle swelling, stiffness, and tea-color urine [1]
This paper reports a total of 29 cases with crayfish-related rhabdomyolysis (Haff disease), clarifies the epidemiological characteristics and clinical features in China, and improves the level of clinical diagnosis and treatment
Emergency Medicine International were collected, and blood routine, biochemical, coagulation function, and arterial blood gas analyses were tested. Those with a positive ingestion crayfish or other history of aquatic products within 24 hours, with markedly elevated serum creatine phosphokinase, and with CK isoenzyme type MB (CK-MB) less than 5% of CK [8] were enrolled; rhabdomyolysis caused by other definite reasons such as trauma and drugs was excluded

Summary

Introduction

Rhabdomyolysis (RM) is a group of clinical syndromes, which is characterized by myalgia, myasthenia, muscle swelling, stiffness, and tea-color urine [1]. Haff disease is a clinical syndrome characterized by myalgia and other symptoms within 24 hours after the consumption of fish or shrimp, often accompanied by myoglobinuria [5]. Diaz et al [6] searched literatures and found that there were only 54 cases of Haff disease in China. This disease is still rare in China, which leads to the possibility of delayed diagnosis in clinical practice. This paper reports a total of 29 cases with crayfish-related rhabdomyolysis (Haff disease), clarifies the epidemiological characteristics and clinical features in China, and improves the level of clinical diagnosis and treatment

Methods

Results

Conclusion