A retrospecti and #775;ve evaluation of the epitelial lesions / neoplasms of the gallbladder in Usak city and determination of the visual frequency

Abstract

Cholecystectomy is one of the most common types of surgical operations and includes many pathologies ranging from the most common cholecysistitis to randomly detected dysplasia and cancer. In this study, it is aimed to obtain a general regional incidence by documenting gallbladder pathology data in Usak province and to contribute to literature in this field. Between 2015 and 2019, 1712 cholecystectomy specimens were analyzed retrospectively in the Department of Pathology, Usak University Training and Research Hospital; adenocarcinoma (primary invasive carcinomas), low and high grade dysplasias (Biliary intraepithelial neoplasia - BillN1,2 ), neoplasms / adenomas, intestinal – pyloric metaplasia, reactive atypia and other lesions were re-evaluated with Olympus CX41 light microscope and based on recent diagnoses. Epithelial changes / lesions were reported in 11.3% of cholecystectomy materials. Of these epithelial lesions, 6.18% had adenocarcinoma, 4,6% had high-grade dysplasia, 29,3% had low-grade dysplasia, 27,3% reactive / regenerative atypia and 2,06% - 14,9% - 15,4 %, neoplastic polyps, intestinal metaplasia and intestinal + pyloric metaplasic respectively. Of the cases with dysplasia and carcinoma, 39.3% and 33.4% were male, 60.7% and 66% female, respectively. The mean age was 57 in dysplasia and 66 in carcinoma. The female / male ratio in carcinoma cases was 2/1 and 41.6% of these cases had stones. The remaining lesions (88,7%) were non-neoplastic polypoid / hyperplastic leions and pyloric metaplasia. According to our findings, we suggest that, even in the absence of clinical symptoms, an adequate number of samples should be taken from the specimen during histopathological examination, especially in elderly women with long-standing stones due to the risk of developing precancerous lesions.