A Responder Analysis To Demonstrate Dupilumab Treatment Effect Across Objective and Patient-Reported Subjective Endpoints For Patients with Severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

Claus Bachert,Anju Peters,Enrico Heffler,Joseph Han,Heidi Olze,Oliver Pfaar,Chien-Chia Chuang,Raj Rout,Richa Attre,Ledia Goga,Juby Jacob-Nara,Paul Rowe,Yamo Deniz,Zhen Chen,Siddhesh Kamat,Shahid Siddiqui

doi:10.1016/j.jaci.2020.12.483

Abstract

Dupilumab has demonstrated reduction in nasal polyp score (NPS) and individual symptom scores in patients with severe CRSwNP; however, combined responder analyses using these endpoints have not been conducted. This post hoc analysis explored the overall effect of dupilumab across both objective and patient-reported subjective endpoints.

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