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Abstract
Abstract. We report on a requirement for the continued presence of a heart graft in the maintenance of systemic tolerance induced by cyclosporin A (CyA). Hearts from DA rats (RT1a) were grafted into PVG (RT1c) recipient. CyA-induced long-term survivors (LTS) bearing functioning heart grafts are systemically tolerant, as demonstrated by the significant prolongation (> 50 days) of donor-strain skin grafts. In contrast, donor-strain skins grafted 3 weeks after the removal of heart grafts from LTS are acutely rejected (median survival 10.0 days; P < 0.005). Using an adoptive transfer assay, 5 |MX 107splenic lymphocytes obtained from LTS 3 weeks after the removal of the heart grafts fail to mediate adoptive tolerance (median survival 17.0 days), in contrast to the tolerance achieved by splenic lymphocytes obtained from LTS with functioning heart grafts (median survival > 100 days; P <0.005).
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