A report of Lead poisoning in two mixed-German shepherd dogs in Babolsar, north of Iran

Abstract

In veterinary medicine, lead poisoning is most common in dogs and cattle. Some sources of lead include: paint, linoleum, grease, lead weights, lead shot and etc. absorption of lead is greater in young animals and low dietary calcium may increase absorption. Lead may cross the blood-brain barrier in greater amounts in young animals. Lead has profound effect on sulfhydryl-containing enzymes and tissues rich in mitochondria, which is reflected in the clinical syndrome. The prominent clinical signs are associated with the GI and nervous system. In the summer of 2007, two mixed-German shepherd dogs (ages: 14 & 16 months) which were being held as guard dogs in a creel making factory, were referred to a clinician in Babolsar. Their abnormal signs were: convulsions, unusual behavior such as continuous running and barking, and pressing their heads to walls and other hard surfaces. Taking the history and epidemiological inspections of the factory revealed that the animals were concealing their bone meal (as their bad habit) in to the lead soil which was being collected at the corner of the factory yard. Thus, that is resulted in providing a base for continuous exposure and digestion of lead for them. Consequently, chelation therapy was initiated by use of D-penicillamine (100 mg/kg/day po. For 7 days). Additionally, Diazepam (0.27 mg/kg/day for 3 days) was administered to dogs in order to alleviate their convulsions. Fluid therapy and corticosteroids were also used as supportive treatment. Partially Improvement was seen b y 3days and all of the clinical signs were completely suppressed one week later.