Abstract
A remotely controlled system has been developed for the routine production of [methyl- 11C]thymidine starting from [ 11C]methyl iodide. The system features semi-automated operation from [ 11C]methyl iodide production over the [ 11C] methylation reaction, HPLC purification to filtration of the final product and collection in a sterile vial. The preparations are completed within 45 min after irradiation and ca 7.4 GBq (0.2 Ci) chemically and radiochemically pure [methyl- 11C]thymidine are produced with a sp. act. of 11 GBq μmol −1 (0.3 Ci μmol −1) at the end of production. Sterile and pyrogen free [methyl- 11C]thymidine suitable for animal and human injections is prepared routinely using this synthesis system. The technical set up is also useful for the production of other nucleosides like: 5-ethyl-[ 11C]-2′-deoxyuridine and 6-methyl-[ 11C]-2′-deoxyuridine.
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Schedule a callMore From: International Journal of Radiation Applications & Instrumentation. Part A, Applied Radiation & Isotopes
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