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Abstract
A rapid, simple, and reliable method for the simultaneous estimation of D and O-MD in plasma and brain is described. These compounds are eluted together, but separately from the catecholamines, by passing perchloric acid extracts through columns of a strong cation-exchange resin in the H + form. The pH of the eluate is adjusted with the addition of a Na 3 citrate solution. Specific oxidation of D and O-MD are carried out by reacting with iodine and ferricyanide, respectively. No interference with plasma D and O-MD measurements was found from the presence in plasma of drugs commonly used in the treatment of parkinsonism. The presence of hydrazinomethyldopa and α-methyldopa partially interferes with the determinations of D and O-MD. Plasma levels of O-MD are greater than D in patients receiving chronic l-dopa therapy.
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