A relationship study on ambulatory pulse pressure, pulse pressure index and cognitive function in vascular cognitive impairment patients

Abstract

Objective To assess the relationship between ambulatory pulse pressure (PP), pulse pressure indices (PPI) and the severity of cognitive function. Methods Sixty patients with severe, moderate, mild vascular cognitive impairment(VCI) as the research object, and forty healthy people as control group.All of the patients of ambulatory blood pressure were monitored. Results Severe VCI group of PP and PPI was significantly higher than moderate, mild VCI group and the control group(PP(mmHg): (59.10±11.82, 54.94±10.86, 50.28±8.33, 45.54±9.22, P<0.05), PPI: (0.61±0.08, 0.53±0.06, 0.44±0.05, 0.37±0.03, P<0.05), and the MMSE score was significantly lower than moderate, mild, and the control group(15.56±2.64, 19.32±3.32, 22.62±3.11, 26.45±2.94, P<0.05). Moderate VCI group of PP and PPI was significantly higher than the control group(P<0.05). MMSE score was significantly lower than mild VCI and the control group(P<0.05). Linear correlation analysis showed that PP and PPI was significantly negative related to MMSE score. Conclusion The increase of dynamic pulse pressure, pulse pressure index is associated with the damage of cognitive function. Key words: Ambulatory pulse pressure; Pulse pressure index; Cognitive function