Abstract
Frogs ( Rana pipiens) adapted to an intermediate state of melanin dispersion were treated with phentolamine and with propranolol in order to block, respectively, alpha and beta adrenergic receptors. Changes in fine structure of the pars intermedia gland cells indicate that adrenergic receptors of both types are involved in the process of MSH release from the pituitary. It is probable that the adrenergic inhibitory control of MSH release in this species is mediated by receptors of the beta type. It is also suggested that alpha adrenergic receptors are involved in the modulation and perhaps facilitation of MSH output.
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