Abstract
Levels of homovanillic acid in striatum and chlorpromazine in brain and plasma of rats after acute and chronic treatment were determined by mass fragmentography. A significant positive correlation was found between the striatal homovanillic acid level and the chlorpromazine concentration in brain after acute as well as chronic treatment. A significant relation was also obtained between the homovanillic acid level in striatum and the chlorpromazine content of plasma after acute but not chronic treatment. After chronic treatment the drug concentration-effect relationship was significantly displaced to the right which may indicate the development of pharmacodynamic tolerance to the effect of the drug.
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