Abstract
Bromolactonization of 2-substituted-1-cyclohexenyl-1-acetic acids with 1,3-dibromo-5,5-dimethylhydantoin (DBH) and potassium tertiary butoxide (t-BuOK) in anhydrous DMF was found to proceed in a highly regioselective manner. The reaction predominantly resulted in the formation of β-lactones (greater than 96%).
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