Abstract
The administration of drugs such as fenfluramine, p-chlorophenylalanine or 5,7-dihydroxytryptamine, which lower brain 5-hydroxytryptamine content, increases the enkephalin content of hypothalamus and striatum. None of these treatmentschanges proenkephalin mRNA content. On the basis of these results, we propose that 5-hydroxytryptamine does not increase the biosynthesis of enkephalin, but might increase the content of the neuropeptide by reducing peptide utilization.
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