Abstract
A novel and simple strategy for preparing a redox-responsive supramolecular hydrogel coassembled from phenylalanine derivative gelator and 4,4′-dipyridine disulfide is reported in this study. The driving force for the coassembly process is intermolecular hydrogen bonds, as confirmed by various characterization methods, such as 1H NMR, Fourier transform infrared (FTIR) spectroscopy, and circular dichroism spectroscopy. The disulfide-containing nanofibrous hydrogel is able to control over the release of encapsulated dyes in response to the reductive condition mimicking the intracellular environment like tumor tissues and should be a promising system for controllable drug release in the fields of nanomedicine and cancer therapy.
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