Abstract
The controlled and target‐specific release of CO to a target site upon photoactivation has recently emerged as a promising tool for targeted anticancer activity. However, the present CO‐releasing molecules (CORMs) suffer several limitations, including poor delivery to the tumor site. In this study, we reported the synthesis, characterization, and caspase 3/7‐dependent apoptosis (IC50: 232 μg ml−1 or 29.03 nM) in A549 cells by manganese(I) carbonyl‐functionalized gold nanoparticles (1‐AuNPs) on dual photosensitization in red light (600–720 nm, 30 J cm−2). The 1‐AuNPs, however, remained nontoxic to A549 cells in the dark. The Mn(I)–CO complex (1) exhibited photocytotoxicity (IC50: 38.1 μM in red light; IC50: 88 μM in dark) as well. Dual photosensitization with red light leading to rapid, synergic CO release and singlet oxygen (1O2) generation were the principal mechanism for the photocytotoxicity, which was studied in detail. Photoactivated CO release resulted in TURN‐ON luminescence in A549 cells and renders the hybrid 1‐AuNPs an ideal, next‐generation nanotheranostic agent.
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