A receptor tyrosine kinase signals to YAP

Abstract

Cancer The Hippo pathway limits cell proliferation by inhibiting the activity of the transcriptional coactivator YAP. In contrast, cell proliferation is stimulated by the binding of growth factors to tyrosine receptor kinases, such as the binding of neuregulin to ERBB4. Neuregulin binding also triggers the cleavage of ERBB4. Haskins et al. found that a fragment containing the intracellular domain of ERBB4 interacted with and activated YAP (see the Perspective by Sudol). Breast cancer cell migration induced by neuregulin was blocked by knocking down YAP. Thus, ERBB4 could promote tumor aggressiveness both through receptor tyrosine kinase signaling and by stimulating YAP. Sci. Signal. 7 , ra116 and pe29 (2014).