Abstract
AbstractNausea/vomiting remains a significant problem in medicine, especially in patients with chronic illnesses. The incidence and patient distress level from nausea/vomiting are underestimated by health care providers. A thorough patient evaluation followed by rational polypharmacy and a multimodal treatment approach may minimize the occurrence and intensity of nausea/vomiting. Utilizing new techniques (e.g., PET imaging of the CNS with novel radiotracers), clinicians may be better able to elucidate which receptors may be contributing to an individual's experience of nausea/vomiting and the relative importance of each. Future research into assessing precise mechanisms of nausea/vomiting in a particular patient may enable clinicians to design the most appropriate combinations of antiemetics in efforts to achieve the most effective therapy with the least side effects. Individually-tailored antiemetic “cocktails,” based on patient specific pathophysiology, may lead to optimal treatment outcomes.
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