Abstract
Ammodytoxin A (AtxA) is the most toxic secreted phospholipase A2 of the three isotoxins with presynaptic neurotoxicity, isolated from the venom of the nose-horned viper (Vipera ammodytes ammodytes), with an LD50 of 21 μg/kg in mice. The toxic potencies of two other isoforms have been re-evaluated using highly purified recombinant proteins, with their intraperitoneal LD50s determined as 960 μg/kg for AtxB and 310 μg/kg for AtxC. AtxB and AtxC differ from AtxA in only three and two amino acid residues, respectively.
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