Abstract

Kikuchi-Fujimoto Disease (KFD) is also known as Histiocytic Necrotizing Lymphadenitis. It is very rare, noncancerous and self-limiting Auto-Immune disease but mostly suspected as cancer, tuberculosis and systemic lupus erythematosus. It has symptoms such as cervical lymphadenopathy (enlargement of lymph nodes), low fever, headache, fatigue, night sweats and muscles pain. It typically affects young females aged between 20-35 years and mostly affects Asian populations. The main identification of KFD is characterized by Fine Needle Aspiration Cytology by taking blood sample from the swollen lymph node. Diagnosis is also possible with Fine Needle Aspiration Biopsy. Treatment for this disease has not been established. Non-steroidal Anti-Inflammatory Drugs or steroids are in use to ease the tenderness of lymph node and fever.

Highlights

  • Introduction are lymphadenopathy, fever, muscle pain, night sweats and weight loss

  • If we look at the countries where Kikuchi female patients were reported, three females were affected with Kikuchi-Fujimoto Disease (KFD) in United States (2008)

  • In Italy (2016), 66 years old female was suffered with two months history of fever which was diagnosed as Kikuchi (Figure 2)

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Summary

Introduction

Introduction are lymphadenopathy, fever, muscle pain, night sweats and weight loss. It is widespread among young female adults in Asia. Kikuchi-Fujimoto (KFD) is benign, self-limiting auto-immune disease which is characterized by lymphadentis and continuous fever. Reports of the patients suggested that the pathogenesis might be auto-immune disease. Clinical features are shown by the occurrence of cervical lymphadenopathy (affecting the lymph nodes) in about 90% cases, which is usually present in trapezius and carotid lymph nodes and observed in patients.

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