Abstract
A reassessment of the low molecular weight phospholipase A2 gene family in mammals.
Highlights
The nomenclature of Phospholipase A2s (PLA2s) enzyme groups distinguished on the basis of structural and other criteria has been reviewed by Dennis [1, 2] and adopted here
All of the ϳ14-kDa PLA2s contain an even number of Cys at characteristic positions, each of which pairs with another specific Cys to form a disulfide bridge, producing a rigid three-dimensional structure
Group IIA PLA2, which has been described for many mammals, and group IIB PLA2, which has only been observed in the Gabon viper, contain 14 Cys residues but, in contrast to the group I enzymes, lack the Cys-11 to Cys-77 disulfide bridge
Summary
The nomenclature of PLA2 enzyme groups distinguished on the basis of structural and other criteria has been reviewed by Dennis [1, 2] and adopted here. The group IIC enzyme from mouse and rat contains only 17 of the 18 amino acids that had been thought to be invariantly conserved in low molecular weight PLA2s [14, 15], Ile-9 being replaced by Val. Rodent group IIC PLA2 is highly expressed in adult but not prepubescent testis [5].
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