A reappraisal of the diagnosis of growth hormone deficiency

Abstract

Cut-off values for the peak growth hormone level after an arginine plus growth hormone releasing hormone (Arg-GHRH) stimulation test for the diagnosis of growth hormone deficiency might require adjustment for young adults with obesity. Abdominal obesity is a stronger predictor of the growth hormone response to Arg-GHRH stimulation than BMI or age, and should be considered in adult patients who are evaluated for growth hormone deficiency.