A REANALYSIS OF 409 EUROPEAN-ANCESTRY AND AFRICAN AMERICAN SCHIZOPHRENIA PEDIGREES REVEALS SIGNIFICANT LINKAGE TO 8p23.3 WITH EVIDENCE OF LOCUS HETEROGENEITY

Abstract

As part of a EUROMET project to produce a range of γ-ray emitting radioactive spiked reference materials, a technique, based on analysis of variance, was developed to evaluate the uncertainties in characterising such materials. A particular concern was to ensure that users of these materials are properly informed regarding the consequences of any remaining inhomogeneities in them. A minimum of five random samples of each reference material were counted six times on a suitable γ-ray spectrometer. Once all of the data were collected and normalised, between-sample (MSBS) and within-sample (MSWS) variances were calculated. The quantity MSWS includes factors associated with sample measurement such as counting statistics, background stability, detector response stability, source-to-detector geometry and electronic stability. The quantity MSBS includes not only all of the terms in MSWS, but also includes terms for sample inhomogeneity, mass determination and density determination. These quantities enable the following calculation to be performed; where σtot is the overall uncertainty, σmeas is the measurement uncertainty and σmat is the uncertainty arising from sample inhomogeneity; it is assumed here that the effects arising from mass and density determinations are negligible. The value of σmat is only valid at the sample weight which it was measured, and data are presented to show the variation of the uncertainty arising from sample inhomogeneity with changing sample weight.