Abstract
Objective: To assess and compare 1-year cardiovascular events occurrence frequency and treatment cost among Chinese coronary heart disease (CHD) or angina pectoris patients who used salvianolate injection or non-user. Method: Data were obtained from electronic medical record (EMR) database between 2012.01.01~2017.12.31 covering medical encounter records from two tier-3 general hospitals from Shanghai and Guangzhou in China. Patients were followed 12 months after drug initiation. T-test, Chi-square test, negative binomial regression and generalized linear model adjusting for demographics, and baseline characteristics including cardiovascular event (myocardial infarction, angina, transient ischemic attack, stroke, etcs) rate, inpatient length of stay, and healthcare resource consumption were used to test the difference between two groups. Result: A total of 439 and 1848 patients were identified for salvianolate injection and control group, with mean (SD) age 75.42 (12.09) and 69.15 (12.79) (p<0.01) and male 43.28% and 52.38% (p<0.01), respectively. During baseline, the mean frequency of cardiovascular events were 2.05 and 5.82 times for treatment and control group respectively (p<0.01); the treatment cost for cardiovascular event were 4720.04 Chinese Yuan (CNY) and 3700.23 CNY for control group respectively (p=0.11). During the follow-up period, the average number of cardiovascular events were 0.26 and 5.87 times for treatment and control group respectively (p<0.01). Compared with non-user, mean per-year cost for salvianolate injection user was 29.58% lower (4069.21 vs. 5778.17 Chinese Yuan (CNY). Conclusion: Among Chinese coronary heart disease and angina pectoris patients, those who used salvianolate injection had lower per-year cardiovascular event rate and spent less on cardiovascular events treatment.
Highlights
Cardiovascular disease (CVD) is the leading global cause of death, an estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths [1]
Coronary heart disease is within the group of cardiovascular diseases of which it is the most common type
A total of 23,265 patients were diagnosed with coronary heart disease or angina pectoris
Summary
Cardiovascular disease (CVD) is the leading global cause of death, an estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths [1]. The number that is expected to grow to more than 23.6 million by 2030 [2]. Cardiovascular disease remains to be the No. cause of death in China, accounting for 40% all cause of death. The current population of cardiovascular disease patient is 290 million, among which the patient number of high blood pressure, stroke and coronary heart disease is 270 million, 13 million and 11 million respectively [3]. Coronary heart disease is within the group of cardiovascular diseases of which it is the most common type.
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