Abstract
Abstract This paper focuses on the design and implementation of on-line optimal control strategies of crystal properties for non-isothermal antisolvent crystallization processes. The one-dimensional Fokker-Planck equation (FPE) is used to represent the dynamic characteristics of the crystal growth and to generate iso-mean and iso-standard deviation curves. Using controllability tools it is shown that the system is ill conditioned in the operational range, posing limitations on the achievable control performance. A novel digital image texturing analysis approach is implemented to track crystal’s size distribution along the experiment, thus providing the on-line information for further feedback control action. Subsequently, alternative control strategies are implemented and tested to achieve a desired crystal size distribution (CSD).
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