"[A]re Norway rats...things?": diversity versus generality in the use of albino rats in experiments on development and sexuality.

Abstract

In America by the 1930s, albino rats had become a kind of generic standard in research on physiology and behavior that de-emphasized diversity across species. However, prior to about 1915, the early work of many of the pioneer rat researchers in America and in central Europe reflected a strong interest in species differences and a deep regard for diversity. These scientists sought broad, often medical, generality, but their quest for generality using a standard animal did not entail a de-emphasis of organic diversity. They chose white rats as test animals for two primary reasons. First, rats develop very slowly. They therefore made features of physiological, neural and psychological development accessible to the experimental method at a time when its application to the phenomena of development remained controversial. Secondly, rats were thought to have unusually strong sex drives. For this reason they became central to the experimental study of sexuality and, in the work of the reproductive physiologist Eugen Steinach, sexual development. Connections among three research institutes that stressed experimental approaches to the study of brain and development demonstrate the importance of the rat's institutional role. As the emphasis on experimentation in the study of development grew, two of these institutes bred rats to provide uniform materials. Eventually, however, their reasons for selecting rats were lost; and the ready availability of a uniform test animal led to a shift in scientists' presumptions about diversity, as the standard rat became a tool for assuring generality.