Abstract
目的 建立环境线索诱导的大鼠海洛因复吸行为模型.方法训练雄性SD大鼠通过鼻触反应进行海洛因静脉自身给药 (每次剂量0.05 mg/kg, 限量每日25次) ,共14d, 每天4h.强化程序为累进比率.起始反应条件为1,每5次海洛因注射后增加1,用灯光作为辨别和条件性刺激信号.停药两周后,大鼠重新返回实验笼进行复吸测试,连续两小时,前1h为实验笼空间环境诱导,后1h为条件性刺激诱导.结果训练7d后大鼠建立稳定的海洛因静脉自身给药行为,获得25次海洛因注射所需时间为(165±16)min,有效鼻触反应为(82±5)次.复吸测试时鼻触反应主要发生在有效鼻触,实验笼空间环境诱导的反应为(28±5)次,条件性刺激为(99±10)次.结论经过一段时间后,海洛因相关的空间环境和条件性刺激可以再次恢复大鼠原来的自身给药反应行为.该模型可用于环境因素诱导的复吸的神经生物学机制研究以及用于与反应恢复模型的比较,作为开发抗复吸模型的有效性有待进一步研究。
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