Abstract
Metastatic ovarian carcinoma to the breast has been documented in 110 cases with an incidence of <1%. Infrequently this can mimic inflammatory breast carcinoma making differentiation between breast and ovarian cancer challenging. Immunohistochemistry (IHC) markers like paired box gene 8 (PAX8) positivity, Wilms’ tumor 1 (WT1) positivity, and gross cystic disease fluid protein 15 (GCDFP-15) negativity, however, can allow for diagnostic certainty. With only seven other cases of metastatic ovarian carcinoma mimicking inflammatory breast cancer, this case is an exceptional and unique find. The patient in this study presented with three months of left breast edema and erythema. Skin biopsies were performed to assess for inflammatory breast cancer. With her recent diagnosis of metastatic ovarian cancer to the breast, metastatic disease was high on the differential. The histopathology results and immunohistochemistry had confirmed the diagnosis
Highlights
Based on statistics from the National Cancer Institute, the lifetime risk of ovarian cancer is approximately 1.3%
Even rarer is metastatic ovarian cancer presenting as inflammatory breast cancer with only seven other cases identified in the literature [2]
With the tumors having psammomatous calcifications and being Wilms’ tumor 1 (WT1) positive, PAX 8 positive, and GCDFP-15 negative, this case was highly suggestive of ovarian carcinoma
Summary
Based on statistics from the National Cancer Institute, the lifetime risk of ovarian cancer is approximately 1.3%. Even rarer is metastatic ovarian cancer presenting as inflammatory breast cancer with only seven other cases identified in the literature [2]. Given the lack of response to a month of antibiotics for suspected mastitis, she was referred to the breast clinic for a skin biopsy to rule out inflammatory breast cancer. Her past medical/surgical history was significant for a gastroesophageal reflux disease and a history of ovarian cancer with total abdominal hysterectomy, bilateral salpingooophorectomy, and omentectomy in 2011. Receptor (ER) and progesterone receptor (PR) negativity on IHC This was consistent with ovarian cancer metastatic to the breast mimicking inflammatory breast cancer, clinically
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