A RARE HIGH GRADE AGGRESSIVE NEUROENDOCRINE CARCINOID OF RECTUM AND ANAL CANAL

Abstract

The synchronous presence of rectal and anal canal neuroendoendocrine tumors account for less than 1% of all rectal malignancies. Immunohistochemistry and positivity for markers such as chromogranin A or synaptophysin are used to identify them. The high proliferative index, Ki67, further classies them as neuroendocrine carcinoid. Here, we present a rare case of a female in her third decade of life who presented with a history of altered bowel habits and was later diagnosed with a high-grade neuroendocrine carcinoid of the rectum and anal canal, Grade 3. The rapidity with which it spreads and metastasizes, combined with the high rate of recurrence, presents a management challenge and a poor prognosis