A RARE GIANT EXTRA-GASTROINTESTINAL STROMAL TUMOR (GIST) IN A YOUNG MALE PATIENT

Miljan Zindović,Velimir Milošević,Aleksandar Kujović,Ljiljana Vučković,Ranko Lazović,Janko Žujović

doi:10.5633/amm.2014.0407

Abstract

Gastrointestinal stromal tumors (GIST-s) are the most common mesenchimal tumors. They occur usually in older age, through the whole digestive tube, but predominantly in the stomach (60%), and most rarely in oesopagus (<1%). Symptoms and signs of GISTs depend on the size and localization of the tumor. Diagnosis is based on pathohistological analyses that include immuno-histochemical staining. Prognosis of these tumors depend of mitotic index, size of tumor, localization, presence of necrosis, bleeding in tumor, infiltration of mucosa and serosa, presence of lymphogenic and liver metastasis. Regarding these parameters, GISTs are classified as high, intermediate, low or very low risk tumors. Standard therapy for GISTs is surgical treatment, and adjuvant treatment with inhibitors of tyrosine kinase depends on risk stratification. In this paper, the case of 37-year old male with giant GIST of extraintestinal localization is described. Tumors of this localization are extremely rare, and data about this issue in literature are scarce. Acta Medica Medianae 2014;53(4):37-41.

Highlights

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract
When it comes to GIST histogenesis, it is accepted that these tumors originate from interstitial Cajal cells, which come up from autonomous nervous system and are in charge of regulation of the gastrointestinal tract motility
There are some opinions that GISTs rise from primitive cells of the gastrointestinal tract, which can differentiate into Cajal cells, and that could explain the appearance of these tumors in the omentum, mesenterium, retroperitoneum or gallbladder, meaning outside of the wall of digestive tube, where Cajal cells normally are not present [17]

Summary

Case report

A RARE GIANT EXTRA-GASTROINTESTINAL STROMAL TUMOR (GIST) IN A YOUNG MALE PATIENT. Miljan Zindović, Velimir Milošević, Janko Žujović, Ljiljana Vučković, Aleksandar Kujović, Ranko Lazović. Diagnosis is based on pathohistological analyses that include immuno-histochemical staining Prognosis of these tumors depend of mitotic index, size of tumor, localization, presence of necrosis, bleeding in tumor, infiltration of mucosa and serosa, presence of lymphogenic and liver metastasis. Regarding these parameters, GISTs are classified as high, intermediate, low or very low risk tumors. The case of 37-year old male with giant GIST of extraintestinal localization is described. Tumors of this localization are extremely rare, and data about this issue in literature are scarce.

Introduction

Findings

Discussion

Conclusion