A rare co-occurrence of Sweet's syndrome and leukemia cutis as a presenting feature of B-cell chronic lymphoid leukemia: Probably a first reported case

Abstract

Sweet's syndrome (SS), also known as acute febrile neutrophilic dermatosis, is characterized by tender, red inflammatory papules or nodules with fever that occur in association with infection, malignancy, connective tissue disease, or drug exposure. Malignancy-related SS has been described mainly in patients with acute myeloblastic leukemia. Leukemia cutis (LC) is the infiltration of neoplastic leukocytes or their precursors into epidermis, dermis, or subcutis, resulting in clinically identifiable cutaneous lesions. LC and its co-occurrence with SS have been described as presenting feature of acute myeloblastic leukemia. There are only few case reports describing SS in patients of chronic lymphocytic leukemia (CLL). However, through literature search, we could not find out cases describing co-occurrence of SS and LC in patients of CLL. Here, we report a rare co-occurrence of SS with LC in case of B-cell CLL, probably first reported case.