Abstract
IntroductionMultinodular goiter is defined as multiple discrete nodules in the thyroid gland. The incidence of Papillary carcinoma thyroid was found to be highest out of total Multinodular Goiter cases while that of Anaplastic carcinoma was the least. We report a rare coexistence of Papillary carcinoma and Anaplastic carcinoma in adult patient with a long-standing Multinodular Goiter. Case presentationHere we present a case of 54 years male with huge anterior neck swelling for 20 years with a gradual increase in size. Computerized tomography of neck revealed solidocystic mass lesion without any significant lymphadenopathy, features suggesting Multinodular goiter with differential diagnosis of Carcinoma Thyroid. Cytological examination showed Papillary thyroid Carcinoma. He underwent total thyroidectomy with central neck dissection. Postoperative period was uneventful. Histopathological report revealed features suggestive of mixed tumor of Papillary thyroid Carcinoma and Anaplastic Carcinoma thyroid TNM Staging T3 N0 M0, Stage IVA. After the final reports patient was sent for adjuvant therapy three weeks later where he received megavoltage external beam radiation and he was followed up till 12th week. He was assessed radiologically which showed no signs of physical progression of the disease. However, he was lost to follow up after that visit. DiscussionLong-standing benign conditions of thyroid can transform into malignant forms in the undefined duration of time. ConclusionRegular follow up and early management of multinodular goiter at the right time can save a patient from undue stress and complication like the conversion into malignancy.
Highlights
Multinodular goiter is defined as multiple discrete nodules in the thyroid gland
Multi-nodular goiter (MNG) can be defined as an enlargement of the thyroid gland with palpable discrete nodules
According to a report by World Health Organization in 2003, worldwide iodine deficiency rate was 9.8–56.9% while goiter prevalence was 4.7–37.3%.When speaking about malignancies in thyroid, Papillary thyroid carcinoma is the most common one.The incidence of Papillary carcinoma is highest in MNG followed by Follicular carcinoma and anaplastic carcinoma [1]
Summary
Multi-nodular goiter (MNG) can be defined as an enlargement of the thyroid gland with palpable discrete nodules. It is more endemic in high mountainous areas like South-East Asia, Latin America and Central Africa. Studies have found the residual areas of papillary carcinoma in the setting of poorly differentiated or undifferentiated carcinomas. They are often termed as mixed tumor or collision tumors. Though the surgical management is the preferred choice for both malignancies, anaplastic carcinoma is followed by adjuvant Radiochemotherapy [15] This case has been reported according to SCARE criteria for case reports (16)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
