Abstract
1. The child presented with a hypertensive emergency and had accompanying hypokalemic metabolic alkalosis. Further investigation revealed low renin activity, low serum aldosterone level, and a normal steroid profile, which is suggestive of Liddle syndrome. Other conditions that present with hypertension, hypokalemia, and suppressed renin activity include the syndrome of apparent mineralocorticoid excess, hyperaldosteronism, glucocorticoid–remediable aldo-steronism (GRA), and congenital adrenal hyperpla-sia, which were all excluded for this patient. 2. Liddle syndrome is caused by hyperactivity of the amiloride-sensitive epithelial sodium channel (ENaC), which is highly selective for sodium. Increased Na reabsorption in the distal convoluted tubules and
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
