Abstract
Sarcoidosis is a multisystem inflammatory disease characterized by the presence of noncaseating granulomas. Sarcoidosis can affect any organ of the body, the lung being the most affected. Sarcoidosis rarely affects the thyroid gland, and only a few cases of thyroid-related sarcoidosis have been reported in the literature. Herein, we report a case of systemic sarcoidosis with multiple organ involvement in a patient with a solitary left thyroid nodule and benign Fine Needle Aspiration (FNA) findings. The patient was eventually diagnosed with thyroid sarcoidosis using a core needle biopsy of the thyroid nodule. With this case report, we highlight the limitations of the FNA. This case report has the objective to encourage clinicians to include thyroid sarcoidosis in the differential diagnosis of thyroid nodules in patients with systemic sarcoidosis even with unremarkable FNA findings.
Highlights
Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that affects individuals worldwide and is characterized pathologically by the presence of noncaseating granulomas in involved organs [1]
We report the case of a middle-aged female who presented for evaluation of hypercalcemia and was found to have systemic sarcoidosis and a solitary left thyroid nodule. e thyroid nodule was found to be unremarkable on Fine Needle Aspiration (FNA), but sarcoid infiltration of the gland was revealed on Core Needle Biopsy
Sarcoidosis is an inflammatory disease characterized by the presence of noncaseating granulomas
Summary
Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that affects individuals worldwide and is characterized pathologically by the presence of noncaseating granulomas in involved organs [1]. 8 percent of patients with sarcoidosis present with disease at extrapulmonary sites without lung involvement. In these patients, the skin is the most common site and accounted for nearly half of the patients [3]. E thyroid nodule was found to be unremarkable on Fine Needle Aspiration (FNA), but sarcoid infiltration of the gland was revealed on Core Needle Biopsy. With this case report, we aim to encourage physicians to include sarcoidosis in the differential diagnosis of thyroid nodules even with normal FNA and recognize the limitations of FNA
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