A rare case of synchronous association of chromophobe renal cell carcinoma with urothelial carcinoma of urinary bladder

Abstract

IntroductionChromophobe renal cell carcinoma accounts for 3–5% of all RCCs. However, its association with urothelial carcinoma of urinary bladder has never been reported. We report a case of synchronous association of chromophobe RCC with low grade urothelial carcinoma of urinary bladder. ObservationsA 64-year old gentleman, presented with a dull aching pain in right loin region of one month duration. General physical and abdominal examinations were unremarkable. Ultrasonography of abdomen showed a well-defined hypoechoic mass lesion involving the lower pole of right kidney. CECT abdomen revealed a partially exophytic mass lesion of size 4cm×4.3cm×5.1cm arising from lower pole of right kidney. Surprisingly, urinary bladder also showed a polypoidal mass lesion measuring 15mm×12mm×13mm in posterior wall inferior to right vesico-ureteric junction. We proceeded with right partial nephrectomy followed by transurethral resection of bladder tumor. Histopathology report revealed chromophobe RCC and low grade urothelial carcinoma of urinary bladder. The patient is under regular follow-up. ConclusionSynchronous association of chromophobe RCC with urothelial carcinoma of urinary bladder has not been reported so far, hence there is no scientific consensus in the management of these lesions.