Abstract
Laryngeal cancer is the 14th most common malignancy worldwide, and its common subtype squamous cell carcinoma (SCC) is highly associated with tobacco use and long-term alcohol consumption. The incidence of distant metastasis from a primary laryngeal cancer has been reported to be very low, between 6.5% and 8.5%, according to published tumour registry data. Distant metastases of laryngeal SCC most commonly involve the lung, liver, bone and mediastinum, seldom involving the kidney. Renal metastasis has been well established in many other cancers such as lymphoma, lung, breast and gastric carcinoma. This report discusses the rare case of a solitary renal metastasis following a primary laryngeal SCC.
Highlights
Laryngeal cancer is the 14th most common malignancy worldwide, and its common subtype squamous cell carcinoma (SCC) is highly associated with tobacco use and long-term alcohol consumption [1]
This report discusses the rare case of a solitary renal metastasis following a primary laryngeal SCC
To the best of our knowledge, this is the fourth report of a primary laryngeal SCC with a metastatic pattern to the kidney and is the first known report of an isolated renal metastasis from a primary laryngeal SCC [6,7,8]
Summary
Laryngeal cancer is the 14th most common malignancy worldwide, and its common subtype squamous cell carcinoma (SCC) is highly associated with tobacco use and long-term alcohol consumption [1]. The patient attended annual reviews by his ear, nose and throat surgeon and did not demonstrate evidence of recurrence He re-presented 42 months later with a 1-week history of right lower quadrant pain and no other associated symptoms. The differential diagnosis included renal cell carcinoma (RCC) He had no haematuria; urine microscopy, culture and sensitivity were normal, and there were no other urological symptoms. The patient underwent a positron emission tomography–magnetic resonance imaging (PET-MRI) scan that demonstrated a right-sided renal hilar mass encasing the renal vessels and showed evidence of invasion into the inferior vena cava (IVC) with possible invasion of the right crus of the diaphragm. The unusual finding of an infiltrative renal hilar mass on CT that did not demonstrate the usual characteristics of RCC on imaging and was not amenable to biopsy was brought to a multidisciplinary team (MDT) meeting for discussion. The patient was referred to a radiation oncologist to discuss the possibility of adjuvant radiotherapy
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