Abstract
A rare complication of chronic lymphedema is development of cutaneous malignant tumors particularly cutaneous lymphomas. We report a case of primary cutaneous diffuse large B-cell lymphoma, leg type, associated with chronic lymphedema of the lower limbs. A literature review identified 12 additional cases of primary cutaneous lymphomas associated with chronic lymphedema. Chronic lymphatic stasis may cause a local dysfunction of the immune system that predisposes to the induction of neoplasia, cutaneous lymphomas in particular.
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