Abstract
Cerebral Aspergillosis (CA) is an opportunistic fungal infection that usually affects immunocompromised hosts. A man was admitted for loss of consciousness and aphasia. Computed Tomography (CT) scan showed a left cerebral frontal lesion. Nasal swab showed hyphae of Aspergillus spp.; isavuconazole was started. Lumbar Puncture (LP) tested positive for galactomannan (index 1.9), and Aspergillus fumigatus grew on the Cerebrospinal Fluid (CSF) culture. Unfortunately, a new episode of fever and a general deterioration then ensued up to the death. In immunocompetent patients as well, chronic fungal rhinosinusitis deserves attention due to its potential for rapid evolution to Central Nervous System (CNS) involvement.
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