Abstract
Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (EMZL-MALT) have been linked to chronic immune stimulation due to infection or autoimmune stimuli. <i>Helicobacter Pylori</i> induced gastric MALT lymphoma is the most extensively documented and well understood. However, in those where <i>H. pylori</i> is not detected, data is less established. Its treatment and prognosis are based on histological evaluation, immunophenotyping, and the use of fluorescence in situ hybridization (FISH), or polymerase chain reaction (PCR) to identify chromosomal translocation and/or unbalanced aberrations.
Highlights
Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (EMZL-MALT) is a relatively rare subtype of lowgrade non-Hodgkin lymphomas [1,2]
We report a rare case of a 71-year-old female with biopsy confirmed H. pylori negative- gastric MALT lymphoma with disseminated disease involving the stomach, small intestine, colon, and lung
fluorescence in situ hybridization (FISH) analysis was positive for BIRC-3-MALT1 (11; 18) fusion, which is seen in approximately 50% of extranodal marginal zone B-cell lymphoma or mucosa associated lymphoid tissue type cases
Summary
Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (EMZL-MALT) is a relatively rare subtype of lowgrade non-Hodgkin lymphomas [1,2]. In the remaining 10% of gastric MALT lymphomas, no H. pylori is detected which renders resistance to antibiotic therapy [5,9,10]. Though the pathogenesis of H. pylori- negative gastric MALT lymphoma is poorly understood, PCR analysis has shown that certain chromosomal abnormalities are often present in high frequencies. We report a rare case of a 71-year-old female with biopsy confirmed H. pylori negative- gastric MALT lymphoma with disseminated disease involving the stomach, small intestine, colon, and lung.
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