Abstract
Functioning adrenocortical oncocytoma is very rare neoplasm. It is usually nonfunctional and benign and incidentally detected. Generally, these tumors originate in the kidneys, thyroid, parathyroid, and salivary or pituitary glands; they have also been reported in other sites including choroid plexus, respiratory tract, and larynx. Histologically, they are characterized by cells with eosinophilic granular cytoplasm and numerous packed mitochondria. We reported a case of a 44-year-old female who presented with Cushing syndrome for hypersecretion of cortisol due to adrenocortical oncocytoma. Magnetic resonance of abdomen revealed a right adrenal mass. Laparoscopic adrenalectomy was performed and the tumor was pathologically confirmed as benign adrenocortical oncocytoma. After surgical treatment, Cushing's syndrome resolved.
Highlights
Adrenocortical oncocytoma is a very uncommon neoplasm, usually considered as benign and nonfunctional
Large size more than 6 cm, heterogeneous appearance, and presence of necrosis or calcification in the tumor pose the doubt for a differential diagnosis with the most likely adrenocortical carcinoma
MR imaging has become increasingly useful in characterizing adrenal masses: the chemical shift allows noninvasive distinction between the fat content of adenomas and the lack of fat within metastases
Summary
Adrenocortical oncocytoma is a very uncommon neoplasm, usually considered as benign and nonfunctional. It produces steroid excess with clinical features such as virilization, feminization, and Cushing’s syndrome [6]. This tumor is characterized by large eosinophilic cells due to the presence of numerous mitochondria [7]. There are no pathognomonic findings on radiological study, but MR is essential for the detection of enlarged lymph nodes suggestive of malignancy [9]. The diagnosis of these neoplasm is essentially based on histological and immunohistochemical analysis. We describe a case of functioning adrenocortical oncocytoma presenting as Cushing’s syndrome
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
