Abstract
The Sri Lanka Journal of Perinatal Medicine (SLJPM) was launched in 2019 as the official journal of the Perinatal Society of Sri Lanka. This journal is unique in the fact that it brings together three core specialties of perinatal medicine - obstetrics, neonatology and community medicine. It is an open access peer reviewed journal containing original research articles, expert reviews, current practices and other articles of interest to all involved in perinatal medicine.
Highlights
Non lymphoblastic leukemia accounts for over2/3rd among reported cases[1], making congenital lymphoblastic leukemia (ALL) an exceedingly rare occurrence
We report a case of congenital B type- Acute lymphoblastic leukemia (ALL) diagnosed at birth with leukemia cutis, generalized lymphadenopathy and asymptomatic pancreatic enlargement which are unusual associations of ALL in neonates
Congenital leukemia manifests as petechiae, echymosis, hepatosplenomegaly, intracranial haemorrhages or otherilldefined symptoms such as poor feeding, fever and failure to thrive. 25% -30% of cases will have leukemia cutis/chloroma due to leukemic infiltrates[3] especially when the disease occurred in-utero. This phenomenon is common in acute myeloid leukemia (AML) and occurs only in 1% of paediatric ALL cases
Summary
Non lymphoblastic leukemia accounts for over2/3rd among reported cases[1], making congenital lymphoblastic leukemia (ALL) an exceedingly rare occurrence It is characterized bymarked leukocytosis, thrombocytopenia and anemia and generally has a poor prognosis even with modern chemotherapeutic regimens. Abdominal examination revealed moderate splenomegaly without hepatomegaly She was the second child of nonconsanguineous parents, and their first baby was healthy at 03 years of age. Antenatal history of this pregnancy was uneventful without features supportive of sepsis, congenital infection, or maternal medical diseases. Hyper-hydration was reduced to maintenance fluid by day 09 of life after white cell count has been normalized
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