Abstract
A one day old female neonate by gestational age of 35 weeks, has clinical features of both collodion baby and harlequin ichthyosis.Coincidence of these two disorders is very rare. Prenatal diagnosis with ultrasonography, fetal skin biopsy, examination of cell from amniotic fluid is possible and can lead to early diagnosis before birth. Morbidity and mortality can reduce by appropriate and immediate treatment. Key word: harlequin ichthyosis, collodionbaby,ectropion, eclabium
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