Abstract

Castleman’s disease (CD) is an uncommon atypical lymphoproliferative disorder with different histological and clinical forms. Patients with the plasma cell type frequently present with systemic symptoms; including fever, weight loss, hemolytic anemia, hypoalbuminemia, hypergammaglobulinemia and increased acute-phase proteins. Renal manifestations like proteinuria or hematuria are common in Castleman’s disease (CD); however, renal complications including minimal change disease, mesangial proliferative glomerulonephritis, membranous glomerulonephritis and nephrotic syndrome also rarely associates with CD. We herein report a patient with fever, weight loss and increase in inflammatory proteins, anemia and declined renal function that was diagnosed as multicentric type CD associated with membranoproliferative glomerulonephritis.

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