Abstract
The angiolymphoid hyperplasia with eosinophilia (ALHE) is considered a rare benign vascular lesion that mainly affects the skin and subcutaneous tissue of the head and neck, but is uncommon in the oral cavity. Its etiology remains unclear and it is described as a reactive vascular proliferation, vascular malformation, or neoplasia. Kimura’s disease is its main differential diagnosis. Here, we report a rare case of ALHE present on the lip of a 50-year-old male patient that exhibited size of approximately 3 cm with 7 years of evolution. After excisional biopsy, the histopathologic examination showed a well-encapsulated and multilobulated lesion with proliferation of blood capillaries that showed endothelial cells of epithelioid appearance, diffuse inflammatory infiltration with lymphocytes, plasma cells, numerous eosinophils, and presence of lymphoid follicles were also found. Immunohistochemical analysis revealed positivity for markers CD34, Bcl-2, and Ki-67 that, together with morphologic examination, support the diagnosis of ALHE.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
