A Rapidly Enlarging Solitary Infantile Myofibroma

Stephany Vittitow,Reza Daughtery,Barrett Zlotoff,Merrick Kozak

doi:10.25251/skin.4.6.21

Stephany Vittitow, Reza Daughtery + Show 2 more

Open Access

https://doi.org/10.25251/skin.4.6.21

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Abstract

Infantile myofibromatosis is a rare disorder of mesenchymal cell proliferation that can affect the skin, bone, muscle, and viscera. We present a case of a 6-week-old male with a rapidly enlarging congenital solitary infantile myofibroma. The differential for congenital tumors of the head and neck is broad, and thorough evaluation is required to rule out life-threatening malignancy. Currently, there is no first-line imaging modality of choice to assess for skeletal and/or visceral involvement in patients with infantile myofibromatosis. We recommend the use of whole-body magnetic resonance imaging (MRI), as it quickly provides detailed information regarding extent of disease and does not expose the patient to the harmful effects of radiation.

Highlights

Infantile myofibromatosis (IM) is a mesenchymal disorder characterized by a fibrous proliferation that can affect the skin, bones, muscle and viscera
Surgical biopsies of infantile myofibromatosis typically demonstrate a proliferation of myofibroblasts with pale eosinophilic cytoplasm that may be arranged in whorled or interlacing fascicles.[2,6]
magnetic resonance imaging (MRI) is an ideal imaging modality to use in the pediatric population, as it spares the patient from ionizing radiation.[7]

Summary

INTRODUCTION

Infantile myofibromatosis (IM) is a mesenchymal disorder characterized by a fibrous proliferation that can affect the skin, bones, muscle and viscera. In order to assess for multicentric and visceral disease, as both morbidity and mortality increase with more extensive involvement. The patient’s mother reported a measured fever of 101.7 degrees Fahrenheit, vomiting, and fussiness He was given a dose of acetaminophen and ceftriaxone at an outside emergency department prior to transfer to our facility. Physical examination revealed a 5cm x 5.5cm firm, non-fluctuant, violaceous nodule with overlying. These findings confirmed a diagnosis of congenital infantile myofibromatosis. Non-contrast computed tomography (CT) revealed no evidence of erosion of the mass into the occipital bone (Figure 2a-d). Histological examination revealed a dermal proliferation of spindled cells with elongated oval nuclei and indistinct eosinophilic cytoplasmic borders.

DISCUSSION

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CONCLUSION