Year-end Sale % OFF 
Abstract
The present study follows the early events in the development of astroglia in rat embryonic (El5) tissue grafted into the cortex of adult rats. Astroglial elements (radial glia and astrocytes) were studied by glial fibrillary acidic protein (GFAP) and vimentin immunohistochemistry on post-transplantation (PT) days 7, 11, 14, 17, and 21. At PT7, GFAP-immunopositive elements were only scarce fibers in the transplants. At PTll, a dense network of long, GFAP-immunopositive fibers enmeshed the entire transplant, and astrocytes were already recognized. The fibers also showed vimentin immunoreactivity. By PT14, astrocytes became the predominant GFAP-labeled elements, although a few long fibers persisted. When compared with in situ development, the grafts showed earlier GFAP-immunoreactivity and earlier appearance of astrocytes, as well as a more rapid transition from the immature to the mature form of the glial system.
Highlights
Neural transplantation is a promising clinical method/8,29/and a powerful tool for studying neurohistogenesis
Several groups have demonstrated the presence of astrocytes in transplants /9,10-12,16,23,37/, the first days of astroglial development after transplantation have not yet been adequately investigated
Our results suggest that the transition of radial glia into astrocytes occurs sooner and more rapidly in the transplanted cortex that it does in situ
Summary
Neural transplantation is a promising clinical method/8,29/and a powerful tool for studying neurohistogenesis. Post-operative events, are crucial for the survival of the transplant, and during this period the transplant can used as a model system for certain neurohistogenetic processes. Experimental evidence has suggested that after a successful transplantation, cell maturation follows a schedule that is similar to that found in situ/9,20,25/. The data from such studies correlate with other observations concerning in vitro development/1,43/. The development and fate of transplanted glia are of interest because grafted immature astroglia can diminish post-lesional neurodegenerative processes /13,32,38,39/ and support axonal regrowth, whereas transplanted oligodendroglial cells are capable of remyelinization/13/. Several groups have demonstrated the presence of astrocytes in transplants /9,10-12,16,23,37/, the first days of astroglial development after transplantation have not yet been adequately investigated
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
