A rapid progressive and fatal case of Non-Hodgkin’s lymphoma in a newly diagnosed HIV patient

Liana-Cătălina Gavriliu,Alina Cozma,Mădălina Simoiu,Cosmina Andrei,Manuela Podani,Roxana Dumitriu,Elisabeta-Otilia Benea,Daniela Camburu,Șerban Benea,Georgeta Ducu,Mihaela Ionică,Nicoleta Bunescu

doi:10.1186/1471-2334-14-s7-p3

Abstract

Background Non-Hodgkin’s lymphoma (NHL) is one of the frequent and severe oncologic pathologies associated with HIV infection. Unlike in immunocompetent patients, this pathology manifests more aggressively in HIV-positive patients, frequently with severe systemic extranodal involvement, affecting the gastrointestinal tract, liver, bone marrow, central nervous system (CNS). Along extranodal involvement, the low level of CD4 at diagnosis, previous history of AIDS-defining illness, the NHL advanced stage, high LDH level and advanced age, are unfavorable prognostic factors for NHL associated with HIV infection.

Highlights

Non-Hodgkin’s lymphoma (NHL) is one of the frequent and severe oncologic pathologies associated with HIV infection
Case report We present the case of a 27 year-old patient, admitted to INBI “Prof. Dr Matei Balş” with axillary tumoral mass with rapid growth in size within past two months, back pain that irradiated towards the lower limbs, abdominal pain, diplopia
Our case illustrates the evolution of an aggressive NHL in a young patient, recently diagnosed with HIV infection, with a good immune status, which is inconsistent with classical prognostic factors

Summary

Open Access

A rapid progressive and fatal case of NonHodgkin’s lymphoma in a newly diagnosed HIV patient. Liana-Cătălina Gavriliu1,2*, Elisabeta-Otilia Benea, Șerban Benea, Roxana Dumitriu, Georgeta Ducu, Daniela Camburu, Alina Cozma, Manuela Podani, Mihaela Ionică, Cosmina Andrei, Mădălina Simoiu, Nicoleta Bunescu. From The 10th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof Dr Matei Bals” Bucharest, Romania.

Background

Conclusion