A Rapid, One-pot, Multi-component Route to 4,4’-(arylmethylene)bis(3methyl1-1-phenyl-H-pyrazol-5-ols)

Abstract

<p>A new, efficient and environmentally benign protocol for the one-pot, multicomponent synthesis of 4,4'-arylmethylene-bis(3-methyl-1-phenyl-1<em>H</em>-pyrazol-5-ols) by condensation of aryl aldehydes, phenyl hydrazine and ethyl acetoacetate catalyzed by Ce(SO<sub>4</sub>)<sub>2</sub><sup>.</sup>4H<sub>2</sub>O as an ecofriendly catalyst with high catalytic activity and reusability at 125 °C under solvent-free conditions is reported.</p><p>The reaction proceeds to completion within 5-12 min in 81-98% yield. This new green methodology is of interest due to minimizing the cost of operational hazards and environmental pollution, its excellent yields, short reaction time and high catalyst activity and reusability.</p>