Abstract
A functional determination of Cl esterase inhibitor (Cl INH) can be easily performed with an amidolytic assay by monitoring the inactivation of plasma kallikrein. In patients with urticaria as well as in healthy donors kallikrein inactivation, determined as the ratio of kallikrein activity at t 60 15 , was found to be 0.47 ± 0.06; in patients with hereditary angioneurotic edema (HANE), however, it amounted to 0.80 ± 0.06. There was a good correlation between the inactivation rate of kallikrein and the protein levels of Cl INH ( r = −0.93, p < 0.001). In the patients with HANE, levels of plasma kallikrein were slightly decreased ( x = 0.37 ± 0.11 U/ml, normal x = 0.47 ± 0.09 U/ml ), but still sufficient for monitoring kallikrein inactivation. In the case of one patient with functionally inactive Cl INH protein, the inactivation of kallikrein was impaired as in the conventional form of the disease.
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