Abstract
Sepsis is a dysregulated host response to infection that causes organ dysfunction and circulatory hypoperfusion...
Highlights
Sepsis is a dysregulated host response to infection that causes organ dysfunction and circulatory hypoperfusion
We have found that pre-binding of Free fatty acids (FFA) and lysoPL to albumin depleted albumin-binding capacity in a FFA/lysoPL dose-dependent manner, and this capacity was completely depleted if albumin was saturated with pre-bound FFA/lysoPL [2]
The SFA assay is a real-time measurement of a specific fraction of albumin binding capacity with bilayer membrane constituents, and the SFA assay can be used as a quantitative measurement to assess the depletion of albumin binding capacity for cell membrane derived FFA and lysoPL
Summary
Sepsis is a dysregulated host response to infection that causes organ dysfunction and circulatory hypoperfusion. In light of the urgency to detect sepsis in its earliest stages, two serum fluorescent assays that we previously developed could be useful for the early diagnosis of infection-triggered sepsis.
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